Association between SCN 5 A gene variant H 558 R and arrhythmias : a systemic review and meta-analysis

Background: The SCN5A H558R polymorphism is potentially associated with several arrhythmias, including Brugada syndrome, atrial fibrillation, and sick sinus syndrome. Here we conducted a comprehensive meta-analysis to investigate the association between this polymorphism and arrhythmia risk. Methods and materials: Eligible studies extracted from the databases of PubMed, Web of Science, and Cochrane Library were evaluated. Statistical analysis was performed using Revman 5.3 and STATA 14.0 software. Results: Five studies with 746 cases and 1085 controls were extracted for the current meta-analysis. The results revealed no significant association was found between SCN5A H558R polymorphism group and arrhythmia risks in all five genetic models. In the stratified analysis of different arrhythmia types, a significantly increased risk of the atrial fibrillation was found to be associated with genotype change in all these five models (AG/AA: OR=1.78, 95% Cl=1.33-2.39, P=0.001; GG/AA: OR=2.76, 95% Cl=1.48-5.16, P=0.001; AG+GG/AA: OR=1.89, 95% Cl=1.43-2.50, P=0.001; GG/AG+AA: OR=2.24, 95% Cl=1.214.13, P=0.01; G/A: OR=1.70, 95% Cl=1.35-2.13, P=0.001). Furthermore, we found that the significantly increased risk of arrhythmias in caucasian was associated with the heterzygous genotype AG in codominant (AG/AA: OR=1.93, 95% Cl=1.50-2.49, P=0.001) and allele (G/A: OR=1.59, 95% Cl=1.30-1.94, P=0.001) models. Conclusion: SCN5A H558R polymorphism may increase the risk of atrial fibrillation and the risk of arrhythmias in caucasian.