Association between gene polymorphisms of PYY and obesity in a central Chinese population

Objective: This study is to investigate the relationship between gene polymorphisms of peptide tyrosine tyrosine (PYY) and obesity in a central Chinese population. Methods: A total of 410 obese patients and an equal number of non-obese volunteers matched by age and sex were enrolled in this study. Blood biochemical indicator detection and physical examination were performed. Genotype analysis and haplotype analysis were undertaken. Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was used for the determination of alleles of PYY in the cohort. Results: The genotype frequencies of AA, AC, CC in rs2880212 and GG, GC, CC in rs2880216 were consistent with the distribution predicted by Hardy-Weinberg equilibrium in the controls (P > 0.5). Addictive model, dominant mode, and recessive model showed significantly different distribution of rs2880412 genotypes AA, AC, CC and rs2880416 genotypes GG, GC, CC in the patients than that of the controls (P < 0.5). Haplotype analysis presented that haplotypes CA and CC could bring risk of obesity (OR, 2.64; 95% CI, 2.00-3.49 and OR, 1.64; 95% CI, 1.01-2.66). There were significant differences in Waist-to-hip ratio (WHtR), systolic blood pressure (SBP), and blood pressure (DBP) in different genotype distribution in site rs2880412 (P < 0.5). And there were significant differences in waist circumference (WC), body mass index (BMI), WHtR, SBP, DBP, triglyceride (TG), and high density lipoprotein cholesterol (HDL-C) in different genotype distribution of rs2880416 (P < 0.5). Conclusion: PYY might contribute to obesity risk in this central Chinese population.