GW26-e1803 Enhanced Expression of A-Disintegrin-and-Metalloproteinase-17 Promotes Extracellular Matrix Remodeling in Rats With Myocardial Infarction

METHODS Forty adult male Wistar rats undergoing MI operation were divided into four subgroups based on survival time: MI1d (at the end of the first day), MI1w (at the end of the first week), MI4w (at the end of the fourth week) and MI12w (at the end of the 12th week). Hemodynamic characteristics were assessed by echocardiography and relative inflammation factors of left ventricular (LV) cavity were measured by ELISA. ADAM17 mRNA level was analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Protein expressions of tumor necrosis factor-a (TNF-a), ADAM17 and tissue inhibitor of metalloproteinases-3 (TIMP-3) in ischemic cardiac tissue were analyzed by Western blot.