The peroxisome proliferator-activated receptor γ agonist 1 pioglitazone prevents NF-κ B activation in cisplatin nephrotoxicity 2 through the reduction of p 65 acetylation via the 3 AMPK-SIRT 1 / p 300 pathway 4

Jiong Zhang , Ying Zhang, Fang Xiao, Yanyan Liu, Jin Wang, Hongyu Gao, Song 5 Rong, Ying Yao, Junhua Li, Gang Xu 6 7 1 Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University 8 of Science and Technology; 9 2 Department of Nephrology, University of Electronic Science and Technology, Sichuan 10 Academy of Sciences & Sichuan Provincial People’s Hospital, Chengdu, China; 11 3 Department of Gastroenterology, Tongji Hospital, Tongji Medical Collge, Huazhong 12 Unversity of science and Technology; 13 4 Department of Nephrology, Hannover Medical School, Hannover, Germany; 14 15 Contribute equally to this work 16 17 Corresponding authors 18 19 Corresponding authors 20 Prof Gang Xu, Tongji Hospital,1095 Jiefang Ave,Wuhan,Hubei, 430030, China. Fax: 21 86-27-83662681; Phone: 86-027-83663613; E-mail: xugang@tjh.tjmu.edu.cn 22 23 Dr Junhua Li, Tongji Hospital, 1095 Jiefang Ave, Wuhan, Hubei, 430030, China. Fax: 24 86-27-83662681; Phone: 86-027-83663613; E-mail: jhli@tjh.tjmu.edu.cn 25 26 Running title 27 Pioglitazone prevents cisplatin nephrotoxicity 28