Methylenetetrahydrofolate Reductase Tagsnps Contribute To The Susceptibility To Type 2 Diabetes In A Chinese Han Population

The potential function of single nucleotide polymorphisms (SNPs) in methylenetetrahydrofolate reductase (MTHFR) gene was predicted to be associated with the risk of type 2 diabetes mellitus (T2DM). The aim of our study was to evaluate the relationship between MTHFR tagging SNPs and the risk of T2DM. A hospital-based case-control study was conducted. Five hundred and two cases with T2DM and 782 controls were recruited. The SNPscan method was used to determine the genotypes. When we used the MTHFR rs4845882 GG homozygote genotype as the reference group, the AA genotype significantly increased the risk of T2DM (AA versus GG: OR = 1.73, 95% CI = 1.02-2.93, P = 0.041). When adjusted for age, sex, smoking, drinking status and BMI, the AA genotype still significantly increased risk of T2DM (AA versus GG: adjusted OR = 1.73, 95% CI = 1.02-2.95, P = 0.044). In the recessive model, when the MTHFR rs4845882 GG/GA genotype was used as the reference group, the AA homozygote genotype was also associated with a significantly increased risk of T2DM (OR = 1.85, 95% CI = 1.10-3.12, P = 0.020). Similarly when adjusted for age, sex, smoking, drinking status and BMI, the AA genotype still significantly increased risk of T2DM (adjusted OR = 1.84, 95% CI = 1.09-3.11, P = 0.024). Our study indicates that the AA genotype of the MTHFR rs4845882 G>A polymorphism significantly increased risk of T2DM in a Chinese Han population.