Synthesis and pharmacological activity of some new α N-Phthalimido amino acids analogues

The aim of the present study was to synthesize and investigate the pharmacological activity of some α N-Phthalimido derivatives of amino acids 2-8. The chemical structures of the titled compound were confirmed by physical and spectra analysis. All the synthesized compounds were evaluated in vivo for analgesic and antiepileptic activities by using standard experimental models. Compound 4 showed significant (P<0.05-0.0001) analgesic effect with hot plate test in mice. The anticonvulsant activity of all compounds were evaluated by picrotoxin -induced seizure . Compounds 3-5 and 7 significantly (P<0.01-0.0001) delayed the onset and antagonized picrotoxin -induced seizures.