Non-structural Proteins 7 and 8 of Feline Coronavirus Form 1 a 2 : 1 Heterotrimer that Exhibits Primer-independent RNA 2 Polymerase Activity

Non-structural Proteins 7 and 8 of Feline Coronavirus Form 1 a 2:1 Heterotrimer that Exhibits Primer-independent RNA 2 Polymerase Activity 3 4 Yibei Xiao†, Qingjun Ma†, Tobias Restle, Weifeng Shang, Dmitri I. 5 Svergun, Rajesh Ponnusamy, Georg Sczakiel, Rolf Hilgenfeld* 6 7 Institute of Biochemistry, Institute of Molecular Medicine, Center for 8 Structural and Cell Biology in Medicine, University of Lübeck, 9 Ratzeburger Allee 160, 23538 Lübeck, Germany 10 Graduate School for Computing in Medicine and Life Sciences, 11 University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany 12 EMBL Hamburg Outstation, c/o DESY, Building 25a, Notkestr. 85, 22603 13 Hamburg, Germany 14 Laboratory for Structural Biology of Infection and Inflammation, c/o 15 DESY, Building 22a, Notkestr. 85, 22603 Hamburg, Germany 16 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 17 555 Zu Chong Zhi Rd., Shanghai 201203, China 18