COD Contact Dermatitis Activation of non-sensitizing or low-sensitizing fragrance substances into potent sensitizers – prehaptens and prohaptens 1

Ann-Therese Karlberg1, Anna Börje1, Jeanne Duus Johansen2, Carola Lidén3, Suresh Rastogi4, David Roberts5, Wolfgang Uter6 and Ian R. White7 1Division of Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden, 2National Allergy Research Centre, Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark, 3 Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden, 4Copenhagen, Denmark, 5School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK, 6Department of Medical Informatics, Biometry and Epidemiology, University Erlangen/Nürnberg, 91054 Erlangen, Germany, and 7Department of Cutaneous Allergy, St John’s Institute of Dermatology, St Thomas’ Hospital, London SE1 7EH, UK