Assessment on microstructure of bone with osteogenesis imperfecta using medical imaging techniques: a review

Osteogenesis imperfecta (OI) is a genetic disease which affecting the bones. In a severe case, this disease can cause the death to the patients. The microstructure of OI bone tissue can be oberseve by variation of imaging technique such as Computer Tomography (CT) scan, Scanning Electron Microscopy (SEM), Fourier Transform Infrared spectroscopy (FTIR) and Magnetic Resonance Imaging (MRI). The observation on microstructural behaviour of OI bone tissue allows more finding on the orientation and behaviour of the damaged tissue in OI. OI bone tissue appears to have less bone mineral density (BMD) than in control group. This information helps in providing the suitable treatment needed by OI patients such as bisphosphate therapy (BP).