A selective extracellular matrix proteomics approach identifies fibronectin proteolysis by ADAMTS 16 and its impact on spheroid morphogenesis

Rahel Schnellmann*1,2,3, Ragna Sack1, Daniel Hess1, Douglas S. Annis4, Deane F. Mosher4, Suneel S. Apte3* and Ruth Chiquet-Ehrismann1,2† 1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland 2Faculty of Science, University of Basel, Basel, Switzerland 3Department of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, United States 4Department of Biomolecular Chemistry, University of Wisconsin, Madison, United States