eart Disease Leaves its Mark roteomics-Based Biosignatures n Acute Coronary Syndromes

n 1990, the Human Genome Project officially began with goal to sequence the entire human genome in 15 years. ith progressive technologic advancements and the contriutions made by international groups and private industry, draft of the human genome was published in 2001, well head of expectations (1,2). This accomplishment has had a rofound impact on the scientific, medical, and pharmaceuical communities and ushered in a new era of diagnostic nd therapeutic discovery. The Human Genome Project dentified 32,000 distinct genes in humans; however, here are many more proteins than genes due to the ost-translational modifications of proteins, making the uman proteome much larger and more complex. roteomics—the comprehensive and systematic study of lobal alterations in protein expression in normal or diseased iologic samples—has emerged as a novel field of study to ddress the technical challenges posed by this complexity.