Study of Paraoxonase 1 And Fibrinogen As An Inflammatory Marker in Essential Hypertension

IntroductionWorldwide, hypertension (HTN) is estimated to cause 7.5 million deaths, about12.8% of total of all annual deaths. It is one of the most important risk factors for cardiovascular diseases and other clinical outcomes. In India prevalence of HTN varies from 17% to 20 %, in all the states with marginal rural-urban difference. Essential hypertension accounts for more than 90% of cases of hypertension. Aim & objective: The present study was carried out with the objective to find out correlation between inflammatory marker like fibrinogen and paraoxonase 1 in hypertension . Methods: The study was carried out on 90 hypertensive patients and 90 normotensive controls. Cases with diabetes mellitus, thyroid disease, chronic kidney disease, smoking, autoimmune diseases and any other chronic diseases are excluded. The study was approved by Institutional ethical committee. Informed consent was obtained from all cases. Serum PON 1 was estimated by ELISA method using commercial kit procured from Aviscera Bioscience and plasma fibrinogen was estimated by tyrosine method (LAMPERT). Result: Plasma fibrinogen was increased and antioxidant enzyme (PON 1) was decreased in primary hypertension in comparison to normal controls (P< 0.001). There was a negative correlation between plasma fibrinogen and serum PON1(r = 0. 971) Conclusion: Fibrinogen, involved in the process of inflammation is increased in primary hypertension. PON 1 is an antioxidant enzyme present on the surface of HDL also significantly decreased which is responsible for prevention of HTN and it’s complications.