Multidocking Studies on 2-Phenyl-4h-Chromen-4-One Hybrid and Evaluation of Anti-Diabetic Activity

The aim of the study was synthesis of ten hybridised flavones and evaluated for anti-diabetic activity. Those compounds were subjected for insilico studies on multi targeted enzymes such as aldose reductase, protein tyrosine phosphatase and alpha amylase for prediction of their biological activity. Based on that result, the titled compounds were revealed for in-vitro and in-vivo anti-diabetic activity. The compound HFd possess high significant (p < 0.01) results and restored the blood glucose level, liver enzymes and renal parameters. Based on docking result, the compound HFd with 2, 4-dimethoxy group on ring C and 7-hydroxy substitution on ring A showed binding interactions with amino acid residues of alpha amylase as Arg 61, Pro 44, His 299, Gln 41 & Asp 96. Hence this article summarised that these scaffolds were acts as a navigator in the management of diabetic mellitus.