1 distinct mutational signatures are associated with correlates of 1 increased immune activity in pancreatic ductal adenocarcinoma 2 3

Ashton A Connor, MD; Robert E Denroche, MSc; Gun Ho Jang, PhD; Lee Timms, MSc; 4 Sangeetha N. Kalimuthu, MD; Iris Selander, MSc; Teresa McPherson, MSc; Gavin W. Wilson, 5 PhD; Michelle A. Chan-Seng-Yue, BSc; Ivan Borozan, PhD; Vincent Ferretti, PhD; Robert C. 6 Grant, MD; Ilinca M. Lungu, MSc; Eithne Costello, PhD; William Greenhalf, PhD; Daniel Palmer, 7 PhD; Paula Ghaneh, PhD; John P. Neoptolemos, MD; Markus Buchler, MD; Gloria Petersen, MD; 8 Sarah Thayer, MD, PhD; Michael A. Hollingsworth, PhD; Alana Sherker, BSc; Daniel 9 Durocher, PhD; Neesha Dhani, MD; David Hedley, MD; Stefano Serra, MD; Aaron Pollett, 10 MD; Michael H.A. Roehrl, MD,PhD; Prashant Bavi, MD; John M.S. Bartlett, Sean Cleary, 11 MD; Julie M. Wilson, PhD; Ludmil B. Alexandrov, PhD; Malcolm Moore, MD; Bradly G. 12 Wouters, PhD; John D. McPherson, PhD; Faiyaz Notta, PhD; Lincoln D. Stein, MD, PhD; 13 Steven Gallinger, MD 14 15 16 PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. 17 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. 18 Hepatobiliary/pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada. 19 Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. 20 Genome Technologies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. 21 Transformative Pathology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. 22 The University of Liverpool, Liverpool, UK 23 Heidelberg University Hospital, Heidelberg, Germany 24 Mayo Clinic, Rochester, MN, USA 25 Massachusetts General Hospital, Boston, MA, USA 26 University of Nebraska Medical Centre, Omaha, NE, US 27 Molecular Genetics Department, University of Toronto, Toronto, Ontario, Canada 28 Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada 29 Department of Pathology, University Health Network, Toronto, Ontario, Canada. 30 Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. 31 Department of Medical Biophysics, University of Toronto, Toronto, ON Canada. 32 BioSpecimen Sciences Program, University Health Network, Toronto, Ontario, Canada. 33 Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico, USA. 34 Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico, USA. 35 36 37 To whom correspondence should be addressed: 38