Does indomethacin exposure increase risk for chronic kidney disease in very low birth weight infants ? 1

Study design: Retrospective chart review including VLBW infants admitted from January 2011-December 2014 at the University of Colorado Level III Neonatal Intensive Care Unit (NICU). Data collected included: indomethacin administration, presence of hypertension, and clinically relevant confounders. The primary outcome was hypertension at discharge. Logistic regression was performed to determine association between indomethacin and hypertension while controlling for confounding variables.