MiR-1505 p Suppresses Colorectal Cancer Cell Migration and Invasion through Targeting MUC 4

Colorectal cancer (CRC) is one of the leading causes of cancer related deaths worldwide (Jemal et al., 2009). Although improved treatment strategies involving surgery, chemoand radio-therapy have increased the overall survival rates in early stages, metastasis and relapse are still the main cause of CRC death. Over the past few years, a large number of miRNAs have been discovered to be correlated with tumor pathogenesis and progression, and miR-150 is one of the most widely researched miRNAs in various kinds of cancer (Lin et al., 2008; Wu et al., 2010; Watanabe et al., 2011). However, there are few researches about miR150-5p in CRC was reported. Previous studies shown that miR-150-5p was low expressed in CRC tissues (Ma et al., 2012; Pizzini et al., 2013), and patients whose tumors had low miR-150-5p expression had shorter survival and a worse response to adjuvant chemotherapy than patients whose tumors had high miRNA expression (Ma et al., 2012), which indicated that miR-150-5p might act as a tumor suppressor gene in CRC. However, the role of miR-150-5p in CRC and its possible mechanism of the action remain to be further explored. MUC4 is a high-molecular weight glycoprotein that belongs to the family of membrane bound mucins (Chaturvedi et al., 2008), which is expressed by epithelial cells in normal respiratory, gastrointestinal and genital tracts (Audie et al., 1993). In cancers originating from these epithelial cells MUC4 is frequently over-expressed