Correlation Research On Estrogen Receptor Alpha Gene And Xba I Pvu Ii And Ppd

Objective: To explore the correlation of polymorphism of Estrogen Receptor-alpha (ER alpha) and postpartum depression (PPD) and provide genetic evidence for the etiology and pathogeny of PPD. And then provide the theory basis to diagnosis and therapy patients in postpartum depression genetically. Methods: Forty-five cases (depressed women postpartum) and forty-five control (non-depressed women postpartum) were selected by the questionnaires. PCR-RFLP was used to examine the polymorphism of Pvu II and Xba I on estrogen receptor alpha (ER alpha), adopt the genetic Numeration to record the allele frequency of depressed group and control group. To analyze the correlations between the polymorphism of Pvu II and Xba I and by Hardy-Welnbery and postpartum depression SPSS18.0. Results: The chi-square test revealed that The genotype distribution of ER alpha and Pvu II in depressed group and control group was significant difference, the difference of allele frequencies (P and p) was significant between depressed group and control group (P<0.05); The chi-square test revealed that the genotype distribution of ER alpha and Xba I in depressed group and control group was no significant difference, The difference of allele frequencies (X and x) was no significant between depressed group and control group (P>0.05), chi-square test indicated that joint genotype distribution ER alpha Pvu II and Xba I was no significant between depressed group and control group (P>0.05). Conclusion: There is relativity between polymorphism of ER alpha Pvu II and postpartum depression (PPD), there isn't relativity between genetic mutation of Xba I and postpartum depression, the analysis of the joint genotype shows that the general genotype distributions of depressed group and control group are similar.