Passive Targeting In Nanomedicine: Fundamental Concepts, Body Interactions, And Clinical Potential

Passive targeting is an important concept in nanomedicine. Passively targeted nanoparticles have been approved by the US Food and Drug Administration for treatment of various diseases, including liquid and solid tumors. In this chapter, we explore the fundamental concepts of passive nanoparticle targeting in the context of cancer nanomedicine. We highlight biological barriers and body interactions that nanoparticles encounter upon systemic administration. The chapter continues with a brief discussion of the clinical relevance of passively targeted nanoparticles. We conclude this chapter by discussing strategies to further improve the potential of targeted nanoparticle approaches for nanomedicine and biomedical applications.