Mixed membership traje ctory models of cognitive impairment in the multicenter AIDS cohort study

Samantha A. Molsberrya,Fabrizio Leccib, Lawrence Kingsleyc, Brian Junkerb,Sandra Reynoldsd,Karl Goodkine, Andrew J. Levinef,Eileen Marting,Eric N. Millerh,Cynthia A. Munroi,Ann Ragink, Ned Sacktorl,James T. Beckera

semanticscholar（2015）

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摘要

Methods: Using data from 3892 men (both HIV-infected and HIV-uninfected) enrolled in the neuropsychology substudy of the MACS, a Mixed Membership Trajectory Model (MMTM) was applied to capture the pathways from normal cognitive function to mild impairment to severe impairment. MMTMs allow the data to identify canonical pathways and to model the effects of risk factors on an individual’s ‘closeness’ to these trajectories.

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