Research on plasma metabolomics of hypertensive rats with liver-fire hyperactivity syndrome

This paper reports a study of plasma metabolites in hypertensive rats with syndrome of liver-fire hyperactivity in order to elucidate the biological basis of hypertension with syndrome of liver-fire hyperactivity. H-1-NMR method was used to identify and compare the small-molecule endogenous metabolites in the plasma of spontaneous hypertensive rats with liver-fire hyperactivity syndrome and normal rats. The results of H-1-NMR pattern recognition showed that hypertensive rats with liver-fire hyperactivity were significantly different from those of the control group. The results of H-1-NMR analysis indicated that there are close relationships between plasma metabolites and TCM syndromes, which is expected to be an objective diagnostic indicator in the further studies.