Chapter 2 Vascular Overgrowth

Blood and lymphatic vessel formation is a vital dynamic process that when dysregulated can lead to excessive or abnormal formation of the vasculature. Vascular malformations are often associated with bony and/or soft tissue hypertrophy (overgrowth) that may occur regionally or involve the whole body. These overgrowth syndromes can be categorized based on the type of vascular malformation present (Table 2.1). The purpose of this review is to provide an overview of the features, pathogenesis, and molecular mechanisms involved in overgrowth syndromes associated with vascular malformations.