Structural Domains in Paramyxovirus Polymerase Independent Structural Domains in the Paramyxovirus Polymerase Protein
semanticscholar(2011)
摘要
Background: RNA-dependent RNA-polymerases of nonsegmented negative-strand RNA viruses (Mononegavirales) harbor multiple catalytic activities. Results: Domain screening and transcomplementation of paramyxovirus polymerase fragments with dimerization tags identifies independent folding-competent domains. Conclusion: Paramyxovirus polymerases harbor at least two independent domains that lack highaffinity interfaces but require molecular compatibility for bioactivity. Significance: First demonstration of Mononegavirales polymerase transcomplementation sets the stage for structural analyses of folding domains.
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