Repeat Polymorphism and Risk of TMPRSS 2 : ERG – Positive Prostate Cancer

Sun Yoo,Andreas Pettersson, Kristina M. Jordahl,Rosina T. Lis,Sara Lindstrom,Allison Meisner,Elizabeth J. Nuttall,Edward C. Stack,Meir J. Stampfer,Peter Kraft,Myles Brown,Massimo Loda,Edward L. Giovannucci,Philip W. Kantoff,Lorelei A. Mucci

semanticscholar（2014）

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摘要

Background: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of patients with prostate

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