Cornea Human Meibum Cholesteryl and Wax Ester Variability With Age , Sex , and Meibomian Gland Dysfunction

Citation: Borchman D, Ramasubramanian A, Foulks GN. Human meibum cholesteryl and wax ester variability with age, sex, and meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2019;60:2286–2293. https:// doi.org/10.1167/iovs.19-26812 PURPOSE. Relationships between tear film lipid (TFL) layer composition, structure, and function could provide insight into the etiology of dry eye. The molar ratio of cholesteryl ester (CE)/wax ester (WE) was measured in meibum from normal donors (Mn) and compared with meibum from donors with meibomian gland dysfunction (MMGD). METHODS. CE/WE was measured using nuclear magnetic resonance spectroscopy.