Ciclodextrinas : como adjuvante tecnológico para melhorar a biodisponibilidade de fármacos Cyclodextrins : as a technological adjuvant to improve drugs bioavailability

Recebido em 08/02/2008 Laboratório de Tecnologia dos Medicamentos/LTM/UFPE SUMMARY – The cyclodextrins use in pharmaceutical applications involving solubilization has exponentially expanded at every decade. This happens because ciclodextrins possesses complexing properties which are capable as providing an increase in solubility, dissolution and biodisponibility of low soluble drugs. Structural natural cyclodextrins derivatives with higher inclusion capability have stimulated pharmaceutical interest, being present in the drugs composition which are actually sale in Europe, Japan and in the United States. The cyclodextrins advantages and application justify its actual use in different pharmaceutical forms. The formation in inclusion complexes is subject to various limited factors, as form, size, and host molecules polarity. Ideal conditions are necessary to obtain an effective molecular capsulation. This means that not all molecules with limited solubility will be complexed. However, recent complexing mechanisms involving ternary and quaternary systems, known as multiple components, have obtained successful results in the complexation efficiency, where the binary system application was neither nor effective advantageous.