Hotspots during Leukemic Transformation of B Cell Precursors Graphical

In Brief B lineage-specific genes are frequently altered in B lymphoid leukemia. Boulianne et al. show that transformed B cell precursors exhibit transcriptioncoupled DNA damage at B lineage genes. Likewise, lymphoid-to-myeloid conversion of transformed B cells induces DNA damage at myeloid loci, suggesting that lineage-specific transcription predisposes lineagespecific genes to subsequent alterations as observed in human leukemia.