Interactions Between Hypoxia-Inducible Factor-1 Alpha And Other Molecules In Cancer: A Literature Review

Hypoxia is a critical characteristic for malignant tumor progression. Transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) plays a fundamental role, assisting with adaption to a hypoxic microenvironment. Multiple target genes can be regulated by HIF-1 alpha, further participating in a variety of biological events of tumorigenesis and tumor progression, including tumor cell proliferation, migration, invasion, metastasis, and angiogenesis. It is worth mentioning that the activity of HIF-1 alpha interacts with several different kinds of molecules and regulators, such as transcription factors, microRNAs, long non-coding RNAs, and signaling pathways. These molecular interactions increase the complexity and difficulty of cancer research. A better understanding of the regulatory mechanisms of HIF-1 alpha with other molecules in cancer will provide deeper insight into HIF-1 alpha and cancer research.