Comparison of Pulmicort 1 pMDI plus Nebuhaler 1 and Pulmicort 1 Turbuhaler 1 in asthmatic patients with dysphonia
semanticscholar(2000)
摘要
Background. Dysphonia is a known local adverse eect of inhaled corticosteroids. This symptom was investigated by laryngoscopy and assessment in a voice laboratory. The eects of changing the treatment of patients with dysphonia, reported whilst using the pMDI, to pMDI plus Nebuhaler or Tubuhaler was also assessed. Methods. Seventy-two patients reporting dysphonia and taking inhaled steroids from a pMDI entered a 12-week, open, parallel group study. Fifty-one completed the study per protocol; 26 in the Nebuhaler group [21 female, mean age 57 years (22±77)] and 25 in the Turbuhaler group [18 female, mean age 58 years (21±81)]. A dysphonia diary card was completed weekly. Voice laboratory assessments and laryngoscopy were performed on entry and at 12 weeks. Results. There were no dierences in voice laboratory data, laryngoscopic evidence of disordered glottic closure and diary data between the two groups at 12 weeks. At study entry laryngoscopic appearances were normal in almost half the patients. Vocal cord bowing was rarely seen. Glottic closure changed in nine patients during the study period, but there was no correlation with voice symptoms. The trend of symptomatic improvement of voice status in the Turbuhaler group did not correlate with voice laboratory assessments and laryngoscopic evidence of disordered glottic closure. After 4 weeks, 40% of patients using Turbuhaler and 8% in the Nebuhaler group scored their voice status as better (P<0?02) but there was no signi®cant dierence between the two groups at 12 weeks (Turbuhaler 52%, Nebuhaler 23%, P=0?08). Conclusion. This study does not support the view that dysphonia in asthmatics inhaling corticosteroids is usually caused by myopathic bowing of the vocal cord muscles.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要