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The E23K polymorphism of the KCNJ11gene is associated with lower insulin release in patients with Autosomal Dominant Polycystic Kidney Disease

Ismail Kocyigit,Sumeyra Dortdudak,Eray Eroglu,Aydin Unal,H. Murat, Sipahioglu,Veli Berk,Bulent Tokgoz,Oktay Oymak

semanticscholar（2022）

Cited 1|Views8
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Abstract
The aim of our study was to investigate an association between E23K KCNJ11 gene polymorphism with anthropometric, biochemical, beta-cell secretion and insulin sensitivity parameters among adult ADPKD patients with normal kidney function and no diagnosis of diabetes. The comparison of genotype-phenotype associations between ADPKD and non-ADPKD subjects could reveal a hypothetical mechanism of genetic determination of diabetes speciic for ADPKD patients.
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