Crystal structures of apo and inhibitor-bound TGF[beta]R2 kinase domain: insights into TGF[beta]R isoform selectivity

Andrew J. Tebben,Maxim Ruzanov,Mian Gao,Dianlin Xie,Susan E. Kiefer,Chunhong Yan,John A. Newitt,Liping Zhang,Kyoung Kim,Hao Lu, M. Lisa, Kopchod,Steven Sheriffa

semanticscholar（2016）

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摘要

PDB references: apo TGF R1-WT, 5e8s; apo TGF R1-T204D, 5e8t; apo TGF R1-8M, 5e8u; apo TGF R2-6M, 5e8v; TGF R1-T204D, complex with staurosporine, 5e8w; TGF R1-8M, complex with staurosporine, 5e8x; TGF R2-6M, complex with staurosporine, 5e8y; TGF R1-T204D, complex with compound 1, 5e8z; TGF R1-8M, complex with compound 1, 5e90; TGF R2-6M, complex with compound 1, 5e91; TGF R2-6M, complex with AMPPNP, 5e92

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关键词

TGF beta R2 kinase domain, apo and inhibitor-bound structures, TGF beta R1 and TGF beta R2 isoform selectivity

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