Formulation and Optimization of PiroxicamNiosomes

The objective of this study was to investigate the bioavailability of piroxicam encapsulated niosomal formulation..Niosomes containing piroxicam were prepared by lipid film hydration technique using Tweens and Spans of varying molecular concentrations with cholesterol. The niosome with the highest entrapment was optimized using varying hydration volumes and time. The optimized niosome was evaluated for drug release using Franz diffusion cell. In-vivo performance of the niosomalpiroxicam was assessed using acute rat paw edema method. Results showed that Tween 60 had the highest entrapment efficiency of 68.5% and on optimization at varying hydration time and volume gave the optimal encapsulation efficiency of 70.2% at 60 s and 3 ml.In-vitro release study showed that the niosomal system gave a gradual release with the maximum release at 120 min.