Functional characterisation of obesity-associated variants involving the alpha and beta isoforms of human SH 2 B 1

Laura R. Pearce#, Ray Joe#, Michael E. Doche, Hsiao-Wen Su, Julia M. Keogh, Elana Henning, Lawrence S. Argetsinger, Elena G. Bochukova, Joel M. Cline, Sumedha Garg, Sadia Saeed, Steven Shoelson, Stephen O’Rahilly, Inês Barroso, Liangyou Rui, I. Sadaf Farooqi#, and Christin Carter-Su# University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK; Graduate Program in Cellular and Molecular Biology, Department of Molecular and Integrative Physiology, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, U.S.A., Joslin Diabetes Center and Department of Medicine, Harvard University, Boston, MA 02115,Wellcome Trust Sanger Institute, Hinxton, UK. Brief Report: