Association of butyrocholinesterase Gene K variant with postoperative delirium in Chinese elderly patients after noncardiac surgery

Association of butyrocholinesterase Gene K variant with postoperative delirium in Chinese elderly patients after noncardiac surgery NI Yu-hua, ZHAO Bao, XING Zhi-qun (1. Department of Healthcare, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, China; 2. Department of SICU, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, China; 3. Department of Critical Care Medicine, Peking Union Medical College Hospital, Beijing 100730, China) Corresponding author: NI Yu-hua, E-mail: niyuhua1980@163.com 【Abstract】 Objective To investigate the relationship between butyrocholinesterase (BChE) gene K variant and postoperative delirium in elderly patients undergoing noncardiac surgery. Method From January 2014 to December 2016, 100 elderly patients with delirium after non-cardiac surgery in Shandong Provincial Hospital Affiliated to Shandong University were included in delirium group, 108 patients without delirium were included in non-delirium group, and the serum BChE activity in the two groups was detected. BChE gene K variant was detected by PCR and direct sequencing method. At the same time, the relationship between BChE genotypes and activities was analyzed. Result Delirium group patients had lower BChE activity than non-delirium group patients (P < 0.05). Genotype distributions and allele frequencies of BCHE gene didn't different between the two groups (P > 0.05). There was no significant difference in the activity of BChE between different genotypes (P > 0.05). Conclusion BCHE gene K variant is not associated with susceptibility to postoperative delirium in elderly patients. 【Key words】 Butyrocholinesterase; Gene polymorphism; Postoperative delirium 丁酰胆碱酯酶基因 K 变异与老年非心脏手术术后 谵妄的相关性研究