Immunological and Histological Response to Cockroach Allergens in Egypt

To evaluate the role of cockroach in allergy formation, detect the antigenic property of such allergen and to assess the significance of variation on IgE level of allergen persons, hamsters were used to be sensitized with cockroach extracts. Treated groups developed positive response to skin damage and recorded elevated total serum IgE-Ab. Histopathological examinations showed degranulation of blood mast cells, increasing of eosinophil cells in number, proving positive response to cockroach allergens. Sections of treated hamster ́s skin appeared the hair with separation at the end of the root sheath and degeneration of epidermal layer. From the results of our study, we support that cockroach antigens are considered an important indoor injected allergens in Egypt. It seems that cockroach control and indoor allergen avoidance measures are among the priorities in the battle against childhood asthma in Egypt.