Therapeutic targeting of the pre-metastatic stage in human lung-to-brain metastasis Running Title : Targeting of Pre-metastasis

Affiliations: Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada Department of Surgery, McMaster University, Hamilton, ON, Canada Krembil Research Institute, University Health Network, Toronto, ON, Canada Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, ON, Canada Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia