Pharmacological Evaluation of Anti – Anaemic Activity of Siddha Herbal Formulation-Madhulai Manappagu

Iron deficiency anaemia is the most common health issue among the women and children in India. Women in the fertile age group and children are more susceptible to be affected by this disorder. It is described as “Veluppu Noi” in Siddha literatures. It is classified as a type of „Azhal‟ humour disorder wherein pallor of the conjunctiva, nailbed, skin, tongue is the chief clinical feature. Untreated anaemia leads to serious consequences of health issues among them and hence management of this disorder is of paramount importance. “Madhulai Manappagu”, a Siddha herbal syrup formulation found in Siddha literatures has been in practice for a quiet long period. Scientific evidences favouring its therapeutic efficacy have to be established. The haematinic efficacy of the manappagu was done by inducing iron deficiency anaemia in rats by giving Phenylhydrazine for 8 days. The animals were grouped in to four groups; Control, disease control, standard Iron syrup and trial drug syrup. Treatment with both the trial drug and the standard iron syrup were continued for 28 days. The blood samples collected from these rats before and after treatment were analysed and the changes in the parameters of Hb, PCV, MCV, MCH, MCHC, PCV, and Serum Iron were noted. The results were analysed statistically and the syrup showed 16.41% improvement in HB levels. This proved the efficacy of this Madhulai Manappagu in treating Veluppu noi. (Iron deficiency anaemia).