Oral bioavailability of cefadroxil in healthy broiler chickens

The pharmacokinetic parameters of cefadroxil (20 mg/kg bwt) were studied following single intravenous (IV) and oral (PO) administrations in healthy broiler chickens. Following a single IV injection of cefadroxil at a dose of 20 mg/kg bwt in healthy chickens, cefadroxil could be detected therapeutically for 24 h. The serum concentration–time curve of cefadroxil following IV injection showed that, the drug obeyed a two compartments open model and the elimination half-life (t0.5β) was 4.85 h, volume of distribution (Vdss) was 629 ml/kg and total body clearance (CLtot) of cefadroxil was 0.185 L/h/kg). Following a single PO administration of 20 mg cefadroxil /kg bwt in healthy chickens, the peak serum concentration (Cmax) was 15.59 μg/ml was achieved at a maximum time (Tmax) of 1.47 h. The oral bioavailability of cefadroxil in healthy chickens was 77.18%.