Divergent Mitochondrial Biogenesis Responses in Human Cardiomyopathy Running title :

5 Div of Biology; Californ nia ia ia I In nstitute of Tec chn h ol log og ogy y; y Pasadena, CA; 6 6 De De D pt pt pt o o of f f Me Me M di di dici ci cine ne ne, , Un Un Univ iv iver er rsi si sity ty ty o of f P Pe enns ns nsyl yl ylva va vani ni n a, a, a P Phi hi hila la lade de delp lp l hi ia, a, a, P P PA A A f f Ad ddr dres ess s f fo for r Co Corr res espo p d nd nde ence ce: : Abstract: Background—Mitochondria are key players in the development and progression of heart failure