Association of Interleukin 1B-511C/T polymorphism with Osteoarthritis, Juvenile Idiopathic Arthritis and Rheumatoid Arthritis susceptibility: a meta-analysis

Background: A number of studies have been conducted to investigate the different types of inflammatory arthritis potential association with the IL-1B -511C/T polymorphism. However, results were inconsistent. We performed this meta-analysis to estimate the association between -511C/T polymorphism and osteoarthritis (OA), juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA). Methods: Electronic search of PubMed and CNKI was conducted to select studies. Studies containing available genotype frequencies of -511C/T were chosen, and pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Results: The final meta-analysis included 17 published studies including 1447 OA cases and 1171 controls, 234 JIA cases and 313 controls, 3524 RA cases and 3111 controls separately. The results suggested that the variant genotype was associated with RA in the total population (additive model: OR 0.925, 95% CI (0.860 similar to 0.995), P = 0.035). However, the association was not significant between this polymorphism and OA (additive model: OR= 1.067, 95% CI: 0.937 similar to 1.214, p= 0.328; dominant model: OR = 0.930, 95% CI: 0.706 similar to 1.225, p= 0.606) or JIA in the total population (additive model: OR= 1.067, 95% CI: 0.821 similar to 1.338, p= 0.626; dominant model: OR = 1.269, 95% CI: 0.843 similar to 1.909, p= 0.254), The stratification by ethnicity failed to identify any association between this polymorphism and OA, JIA, RA in Asian, Caucasian or African groups. Conclusion: This meta-analysis suggests that the allele T of IL-1B -511C/T polymorphism is associated with decreased risk of RA in all ethnicities including Caucasian, Asian and African.