Otka-nnf 78918 " Molecular Diversity and Plasticity of Endocannabinoid Signaling at Cortical Synapses " Publications Supported by the Otka-nnf 78918 Grant Publicity Measures, Participation at Conferences Posters

(2011) Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. (2011) Uncoupling of the endocannabinoid signalosome in a mouse model of fragile X. (2010) Synaptic localization of the enzymatic machinery responsible for 2-arachidonoylglycerol synthesis and degradation in the human hippocampus. Development of perisomatic innervation of pyramidal neurons arising from CB1-and parvalbumin-positive basket cells in the mouse visual cortex. (2010) Synaptic localization of enzymes responsible for the synthesis and degradation of the endocannabinoid 2-arachidonoylglycerol in human hippocampus. Summary of the scientific achievements Specific aim 1 Endocannabinoids (eCBs) are retrograde lipid messengers regulating short-and long-term forms of synaptic plasticity throughout the nervous system (Chevaleyre et al., 2006). The substantial role of the eCB system in neuronal function is well supported by its involvement in various diseases of the CNS (Pacher et al., 2006). Several different mechanisms of eCB-dependent synaptic plasticity have been described in different layers of the neocortex, including stimulation-induced, pairing-induced, and spike-timing dependent depression The exact molecular composition of synaptic eCB signaling is well described in some brain regions, e.g. the hippocampus, where activation of metabotropic glutamate receptors leads to the postsynaptic production of 2-arachidonoylglycerol (2-AG) by diacylglycerol