Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins

Although recombinant human cytokines are commercially available from bacterial, eukaryotic, and mammalian cell expression systems (E. coli, SF9, CHO), human cellexpressed (HEK293) glycoproteins offer the distinct advantage of native human glycosylation. In this Whitepaper, several examples illustrating the importance of correct glycosylation in cytokine activity, stability and half-life, are provided for cytokines widely used in stem cell research. Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins