Gut Flora Metabolite Trimethylamine n-Oxide, Predict Cardiac Events in Patients with Acute Coronary Syndromes

Introduction Recent studies indicate that microbes in the gut can predispose the development of atherosclerosis, chronic kidney disease and the heart failure as well as diabetes. The increase in the concentrations of trimethylamine N-oxide (TMAO) is associated with risks for both prevalent atherosclerotic heart disease and incident major adverse cardiac events in multiple independent cohorts [1-3]. There is evidence that foods such as meat, egg yolks and high fat dairy products appear to be dietary precursors TAMO generation, which is a metabolite that accelerate atherosclerosis and cardio-metabolic diseases (CMDs). These foods are rich sources of choline, phosphatidylcholine and carnitine and hence trimethylamine (TMA).