Intraoperative Radiotherapy with the Use of Low Energy X-Rays for the Treatment of Early Breast Cancer

The present study shows the experience, with the use of partial accelerated Intraoperative Radiation Therapy (IORT) to the breast, by the use of 50kV X-ray system (Karl Zeiss Intrabeam), after conservative surgery, for patients with early breast cancer, describing the short-term results in relation to the tolerance and complications of treatment, and in the medium and long term in relation to tumor relapse and overall survival. 230 patients were included in a period of more than 6 years, median age was 57 years (range 40-86 years), and the median tumor size was 1.4cm (range 0.4 cm – 3.2 cm), criteria of ASTRO and ESTRO were applied for the selection of cases. The median followup was 48 months (range 12-89 months), 31 patients (13.5%) required complementary external radiotherapy, for adverse prognostic factors, acute complications presented in 23% of the cases, the vast majority (94%), were minor complications resolved spontaneously or by a simple procedure in the office (seroma, small dehiscence, edema, mild radioepithelitis). Local recurrence occurred in 4 patients (1.7%), 3 in the surgical bed or scar, and one axillary, in three of four relapses, breast conservation was possible, since they were resolved with local resection and external radiotherapy. Two patients had distant relapse, one bone and one pulmonary, the latter died 10 months after the relapse was documented, and is the only death in the current series. IORT can be considered as an alternative to external total radiotherapy for well-selected patients, who meet criteria of partial radiation therapy to the breast. Antonio Maffuz-Aziz1*, Judith Huerta-Bahena2, Carlos Alberto Domínguez-Reyes1, Juan Alberto Tenorio-Torres1, Santiago Sherwell-Cabello1, Silvia López-Hernández1 and Sergio Rodríguez-Cuevas1 1Department of Surgery, Instituto de Enfermedades de la Mama FUCAM, México 2Department of Radiation Oncology, Instituto de Enfermedades de la Mama FUCAM, México