Unregulating miR-3074-3 p enhanced cell proliferation ability in prostate cancer by suppressing Axin 2

Activation of Wnt/β-catenin pathway promotes development of cancer, Axin2 is the center effector in this pathway. This study is to explore the role of miR-3074-3p in in prostate cancer. In our research, we examined that miR-3074-3p was upregulated in prostate cancer cell lines and tissues. Overexpressing miR-3074-3p promoted, while downregulating miR-3074-3p inhibited the proliferation capacity of prostate cancer cell lines in vitro. Moreover, we found that miR-3074-3p can directly targeted to Axin2 3’-UTR to activate the Wnt/β-catenin signaling pathway, and then further to influence the downstream genes of Wnt/β-catenin signaling pathway to enhance malignance of prostate cancer. In summary, our study inferred that miR-3074-3p took apivotal role on prostate cancer progression and may be acted as a novel therapeutic target of prostate cancer.