Long non coding RNA CCND 2-AS 1 promotes gastric cancer growth through Akt signaling

Gastric cancer (GC) is still the second lethal malignancy worldwide. Mounting evidence indicates that lncRNAs (long-non coding RNAs) play vital roles in tumorigenesis. But, the role of lncRNAs in GC is still largely unclear. Firstly, QRT-PCR were performed to asses lncRNA CCND2-AS1 expression 64 pairs of gastric cancer tissues (case group) and matched non-tumor tissues (control group). Both lossand gain-functions assays were conducted by transfection. The cell viability, proliferation and cell cycle status after transfection were assessed by CCK-8 assay, clone formation assay, and FCM. Our results firstly show that LncRNA CCND2-AS1 is upregulated in GC tissues and cell lines. Moreover, CCND2-AS1 can promote GC cell proliferation and growth through Akt signaling. We demonstrate that CCND2-AS1 promoted GC cell growth via affecting Akt signal pathway and which suggest CCND2-AS1 might act as a potential therapeutic target in GC.