Association Of Polymorphisms In The Cytochrome P450 Gene With Susceptibility To Lead Poisoning In A Chinese Population

The present study is the first to explore the relationship between cytochrome P450 (CYP) polymorphisms and individual susceptibility to lead poisoning. Industrial workers (n = 1057) from five textile factories in east China provided venous blood for measurement of blood lead levels (BLL) and completed questionnaires. Genotyping was then performed for three selected SNPs (rs1048943, rs1056827, and rs1056836) from two CYP genes in blood samples from 287 lead poisoning cases (BLL > 400 mu g/L) and 355 controls (BLL < 200 mu g/L). Subsequently, the main effects of the genotype and its interactions were evaluated. Results revealed that Chinese individuals with the AA genotype of rs1048943 (OR = 3.03) and the haplotype ATC (rs1048943-rs1056827-rs1056836) (OR = 1.85) had an increased risk of lead poisoning. Multifactor dimensionality reduction analysis indicated that rs1048943-rs1056827 and rs1048943-rs1056827-rs1056836 had interactions and were related to increased lead poisoning risk (OR = 1.63 and 1.70, respectively). Overall, present findings indicate that CYP1A1 genetic polymorphism, rs1048943, is associated with an increased risk of lead poisoning in a Chinese population. It may have potential as a biomarker for lead-exposed workers.