ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p 53 protein involving poly ( ADP-ribose ) polymerase block can be overcome upon expression of the SV 40 large

block can be overcome upon expression of the SV40 large Homayoun Vaziri, Michael D.West1, T antigen or the HPV-16 E6/E7 proteins, resulting in an Richard C.Allsopp1, Timothy S.Davison, extension of cellular lifespan (Shay et al., 1993). SV40 Yu-Sung Wu, Cheryl H.Arrowsmith, large T antigen is known to bind the p53 tumor suppressor Guy G.Poirier2 and Samuel Benchimol3 protein and to interfere with its DNA binding and transcrip-