Growth inhibitory effects of Chidamide on breast cancer cells

This study aimed to explore the effects of histone deacetylase inhibitor Chidamide on the proliferation of breast cancer cell lines MCF7 and MDA-MB453. The growth of MCF7 and MDA-MB453 cells were greatly inhibited by Chidamide in both time and dose dependent manners. Chidamide induced cell apoptosis and delayed G2/M cell cycle progression. In addition, chidamide up-regulated the expression of Baxand p21 whereas down-regulated Bcl-2 and Cyclin B2 to promote the cleavage of PARP and caspase-3. In conclusion, Chidamide could induce cell apoptosis and cell cycle arrest to inhibit the growth of MCF7 and MDA-MB453 cells, possibly through regulating the expression of Bax, p21, Bcl-2 and Cyclin B2.