Clinical significance of serum tumor markers CA 153 , CA 125 , CA 724 and FIB , IL-6 levels detection in ovarian cancer

Ovarian disease is a common disease of gynecology; malignant ovarian cancer is seriously endangering female's life, and the morbidity and mortality of ovarian cancer are high. Moreover, because of lack of early typical clinical symptoms of ovarian cancer, it is very difficult to diagnose and differentiate. Therefore, benign and malignant tumors usually need to be surgically confirmed, and often lead to the patient miss the optimal timing of treatment, hence, effective early diagnosis and identification are significant for prognosis and treatment of patients[1]. Serum tumor markers will be specifically expressed in tumor tissues, and different types of tumors usually induce the expression of different types of tumor markers, which has a positive reference value for the detection of malignant tumors[2]. Among them, carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125) and carbohydrate antigen 72-4 (CA72-4) are widely used in the auxiliary examination of ovarian cancer diagnosis. Plasma fibrinogen (FIB), interleukin-6 (IL-6) has also been reported to use for the detection of ovarian cancer[3-5]. In this paper, the levels of CA153, CA125, CA72-4, FIB and IL-6 in serum of ovarian cancer, benign ovarian tumor and healthy female were detected and explore its clinical value in the differential diagnosis of benign and malignant ovarian diseases.