Formulation and in-vitro Evaluation of Captopril Floating Matrix Tablets Using HPMC 50cps

In the present investigation a gas powered tablets (floating tablets) of Captopril were prepared to increase the gastric retention time in order to improve the therapeutic effect of the drug by increasing its bioavailability. Captopril is antihypertensive drug, it is soluble in water; its maximum absorption is from the stomach and upper part of the intestine. The Gas powered tablets were prepared by direct compression method. A present investigation comprises a drug Captopril, a gas generating agent 6 to 18% sodium bicarbonate, water soluble polymers 40 to 60% HPMC 50 cps to get the desired controlled release over a period of 10 hrs. The prepared tablets were subjected to post-compressional parameters such as hardness, friability, weight variation, thickness, drug content, lag time subsequently buoyancy time, and in-vitro dissolution studies. Drug compatibility with excipients was checked by FTIR and DSC studies. The formulations C3 was found to be promising, which shows an in vitro drug release of 91.32% in 10 hrs along with satisfactory floating lag time (2 min.27 sec.). All the formulations exhibited diffusion dominated drug release.